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The most recent study was conducted at Boston Children's Hospital in 2012, looking at 1,749 women with BPH treated at least one BOTOX in the first trimester and compared those with a median age of 36. These women were then randomized to either receive at least four months of the pill at an average dosage of 5 mg estrogen (the equivalent of the combined dose from two pills) or placebo for a median time interval of 10.5 months.
At the 9-month follow-up visit, women taking the estrogen pill experienced a significant reduction free drugstore shipping code in the average total BPH excretion by nearly 30 mL per month (22.1 for those taking estrogen and 19.3 mL for those taking placebo).
The reduction in BPH excretions after the estrogen treatment was significant, which also documented on the urinary excretion of two hormones, estrone and DHEAS.
What is BOTOX?
BOTOX is an injectable progestin made by the Schering-Plough Corporation. It works by mimicking the effects of estrogen by acting as an receptor modulator (ERM) on breast cells. After injectable administration, BOTOX binds to the estrogen receptor and induces a series of physiologic and biochemical events that reduce the amount of estrogen in body.
BOTOX blocks estrogen's action on two estrogen receptors (ERR1 and ERR2), leading to decreased production of prolactin by the pituitary gland, a hormone that stimulates production of breast milk, and decreased production of progesterone by the endocrine glands surrounding breasts. Together these two changes decrease the amount of estrogen in body, which turn decreases the risk of breast cancer.
The exact mechanism by which BOTOX decreases hormone production remains unknown. However, two other studies have demonstrated the hormone can also affect other system in the body. This includes reducing prostaglandin synthesis in the liver Clomiphene 180 Capsules 15mg $420 - $2.33 Per pill and decreasing testosterone production in the adrenal glands.
How Does BOTOX Work?
BOTOX works by reducing the action of estrogen by mimicking the effects of estrogen itself. This mimicking act of estrogen occurs because BOTOX
Atorvastatin 40 mg generika binds to the estrogen receptor 1 (ERR1), which is located on target cells or in cells, including breast cancer where the estrogen is produced. hormone thus becomes less active.
Another mechanism to explain BOTOX's effect is an increase in production of the hormone cortisol, which reduces estrogen's production by changing the balance of hormone production in cells, such as the liver and endometrium. converts aromatase to dihydrotestosterone, a male hormone, which is converted in the cells of endometrium, where progesterone is synthesized.
In both cases, the increase cortisol levels may be responsible for why BOTOX works on breast cancer and not non-breast cancers, such as cervical or pros